New Genetics, Food & Agriculture: Scientific Discoveries - Societal Dilemmas

 

Executive Summary Table 1:  Human Health Effects of Genetically Modified Foods: Areas of Scientific Convergence, Divergence, and Gaps in Knowledge

Issue

Scientific Convergence

Scientific Divergence

Gaps in Knowledge

Safety of currently available GM foods for human consumption

Currently available GM foods are considered safe to eat.

No evidence of any adverse effects from consumption  to date. 

Post-market surveillance is difficult due to confounding effects of diversity of diets and genetic variability in populations.

Long-term effects unknown, both for GM and for most other foods.

How to conduct post-market surveillance?

Future products

(e.g. foods with modified nutritional content)

Need to be assessed on case-by-case basis to ensure pre-market safety, before new foods are brought to market.

Extent of safety analysis should be proportionate to risk.

Product and/or process may be assessed.
 

Unintended effects possible, either through conventional plant breeding or gene technology.

Methods of food safety assessment

Case by case analysis required, using scientifically robust techniques.

Current safety assessment methods, largely based on comparison of a limited number of compounds, may not be adequate to assess more complex products, which are not substantially equivalent to present foods.

 

Whole food analysis is possible, but requires further R&D to validate new techniques and interpretation of data.

Need to know how much change in food content is nutritionally significant. 

Health benefits

Many GM crops are now grown with less pesticide, thereby reducing exposure to chemical pesticides.

In the future, crops may be used to produce new pharmaceutical/medicinal compounds (e.g. vaccines).

Future GM crops may have improved nutritional content (e.g. vitamin A rice).

Need to ensure quality control of new products and keep pharmaceutical products out of the food chain. This may be difficult.

Availability of nutritionally significant levels of vitamins and minerals in GM foods needs to be demonstrated.

Need to demonstrate new crop management practices for novel products, to ensure they can be kept out of the food chain and adequately regulated.

 

Executive Summary Table 2:  Environmental Effects of Living Modified Organisms (LMOs): Areas of Scientific Convergence, Divergence, and Gaps in Knowledge.

Issue

Scientific Convergence

Scientific Divergence

Gaps in Knowledge
 

Direct effects

Agriculture affects the environment. Environmental effects of LMOs may be negative or positive. Requires case-by-case assessment. 

Direct effects of GM crops may include gene flow from GM crops to local land races, and/or compatible wild or weedy relatives in centres of diversity.

Other hazards to assess for plants include any increased potential for:  Weediness; effects on non-target species; unexpected effects; worker safety.

 

Need to compare LMO effects with present agricultural practices and other options for land use.

Gene flow occurs in all open pollinated crops, at varying frequency.

Real question is: Does it matter? Depends if new hybrids survive to form weeds or invasive species.

LMOs may affect non-target species, but difficult to determine significance. Need to compare LMO effects with current practices and other options for crop cultivation.

Baseline ecological data for comparisons are lacking.

Significance of gene flow in centres of crop diversity needs to be investigated further.  Modelling approach may be useful to assess likelihood of gene flow and its significance.

Effects on soil microflora are difficult to detect.

 

 

Indirect effects

GM technology may change agricultural practices.

Less insecticide used on pest tolerant crops. Instances of 40% less insecticide used on Bt cotton. 

Need to avoid development in resistance in pest populations by crop management systems to reduce selection pressure on target pest in Bt crops.

Herbicide use may increase or decrease with use of herbicide tolerant crops.  Weed biology may change in GM crop fields.

Herbicide tolerant crops may be useful for low-till agriculture and improve soil conservation.

Stress tolerant crops may threaten ecosystems (e.g. salinity tolerant rice in mangrove ecosystems).

Pest-resistance management in complex agricultural systems in less developed countries may be difficult.

Need to develop integrated pest management systems, incorporating LMOs where appropriate, and monitor for any changes in populations of beneficial organisms and developments in pest resistance.

 

Methods of environmental impact assessment

Types of data sought for environmental impact assessment are similar, but interpretation varies in different regulatory systems.

Precautionary approaches to manage uncertainty require that new technologies demonstrate no harm. Since biological systems do not deliver certainty, zero risk is an unattainable standard.

Significance of laboratory studies is debatable, as it is difficult to extrapolate from laboratory to field studies and effects of commercial use.

What constitutes an adverse environmental impact?

Need comparative analysis of different systems (LMOs, intensive, subsistence, and/or organic agriculture).

Baseline ecological data for different agricultural systems are difficult to obtain.

Need international harmonization of environmental impact assessment methods and commonly agreed standards.

Biodiversity conservation

Molecular methods help characterize biodiversity.  Genomic studies will help identify genes within species and how to switch them on/off. 

Increasing efficiency of agriculture may threaten biodiversity; it may also protect biodiversity by reducing pressure on natural resources.

Molecular finger-printing of gene bank accessions would be useful, to set baseline data and monitor any genetic changes over time.

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